Structure of PDB 4qxc Chain C Binding Site BS01
Receptor Information
>4qxc Chain C (length=329) Species:
10090
(Mus musculus) [
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RTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLG
IKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEE
EREKLYNVISLEFSHTRLENMVQRPSTVDFIDWVDNMWPRHLKESQTEST
NAILEMQYPKVQKYCLMSVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIP
PTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHA
VYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWY
VLERYVYCITNRSHLTKDFQKESLSMDME
Ligand information
>4qxc Chain F (length=9) Species:
10090
(Mus musculus) [
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ATGGVKKPH
Receptor-Ligand Complex Structure
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PDB
4qxc
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36.
Resolution
1.75 Å
Binding residue
(original residue number in PDB)
M111 Q116 I144 S145 N186 A187 I188 Y199 T209 H212 D214 F215 V220 N298 K323 F324 R325
Binding residue
(residue number reindexed from 1)
M76 Q81 I109 S110 N151 A152 I153 Y164 T174 H177 D179 F180 V185 N263 K288 F289 R290
Enzymatic activity
Enzyme Commision number
1.14.11.27
: [histone H3]-dimethyl-L-lysine(36) demethylase.
External links
PDB
RCSB:4qxc
,
PDBe:4qxc
,
PDBj:4qxc
PDBsum
4qxc
PubMed
25128496
UniProt
P59997
|KDM2A_MOUSE Lysine-specific demethylase 2A (Gene Name=Kdm2a)
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