Structure of PDB 4qtt Chain C Binding Site BS01

Receptor Information
>4qtt Chain C (length=135) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFLTTNFLKCSVKACDTSNDNFPLQYDGSKCQLVQDESIEFNPEFLLNI
VDRVDWPAVLTVAAELGNNALPPTKPSFPSSIQELTDDDMAILNDLHTLL
LQTSIAEGEMKCRNCGHIYYIKNGIPNLLLPPHLV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4qtt Chain C Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4qtt Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		C11 C16 C112 C115
Binding residue
(residue number reindexed from 1)		C11 C16 C112 C115
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008276 protein methyltransferase activity
GO:0016435 rRNA (guanine) methyltransferase activity
GO:0046982 protein heterodimerization activity
GO:0160102 tRNA (guanine(10)-N2)-methyltransferase activity
Biological Process
GO:0000470 maturation of LSU-rRNA
GO:0002098 tRNA wobble uridine modification
GO:0030488 tRNA methylation
GO:0030490 maturation of SSU-rRNA
GO:0042273 ribosomal large subunit biogenesis
GO:0042274 ribosomal small subunit biogenesis
GO:0060566 positive regulation of termination of DNA-templated transcription
GO:0070476 rRNA (guanine-N7)-methylation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0035657 eRF1 methyltransferase complex
GO:0043527 tRNA methyltransferase complex
GO:0043528 tRNA (m2G10) methyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qtt, PDBe:4qtt, PDBj:4qtt
PDBsum4qtt
PubMed25489090
UniProtP53738|TR112_YEAST Multifunctional methyltransferase subunit TRM112 (Gene Name=TRM112)

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