Structure of PDB 4qqx Chain C Binding Site BS01

Receptor Information
>4qqx Chain C (length=899) Species: 269800 (Thermobifida fusca YX) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYLSPGLRDTIAS
SMETDEEHAGHCIAFWAGLHDIGKLTREFQQQIAIDLSAYPGEELSGEQR
SHAAATGKWLPFALPSLGYPNGGLVTGLVAQMLGGHHGTFHPHPSFQSRN
PLAEFGFSSPHWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL
ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPSLLDAAGLRPI
TVPPATFTESFPHLSKPNGLQASLAKHLPCLCTGPGLVLITAPMGEGKTE
AAYHVADLLGKATGRPGRFLALPTMATADQMHTRLKEYARYRVENTSSTL
ALLHSMAWLNPDYAPADPFAATDWLMGRKRGLLAPWAVGTIDQALMAVLR
AKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWLGTLDVPVVLLS
ATLHHSIANSLVKAYLEGARGRRWNRSEPQPVSEVSYPGWLHVDARIGKV
TRSSDVDPLPIATTPRKPLEVRLVDVPVKEGALNRSTVLAKELTPLVKQG
GCAAIICTTVAEAQGVYDLLSQWFATLGEPDLYLLHSRFPNRQRTEITAT
IVDLFGKEGAQSGRRPTRGAVLVATQVVEQSLDLDVDLMISDLAPVSLLL
QRAGRCWRHEHLGIINRPQWAKQPELVVLTPEQNAPWFPRSWTSVYPLAL
LQRTYTLLRRRNGAPVQIPEDVQQLVDDVYDDDSLAEDLEADMERMGEEL
AQRGLARNAVIPDPDDAEDNLNGLTEFSVLATRFGAGSVRVLCYYVDTAG
NRWLDPECTVEFPEQGTGREGRFTMADCRDLVARTIPVRMGPWASQLTED
NHPPEAWRESFYLRDLVLIPQRVTDEGAVLPTETGGREWLLDPCKGLIF
Ligand information
Receptor-Ligand Complex Structure
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PDB4qqx Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Resolution3.34 Å
Binding residue
(original residue number in PDB)		K23 K87 H150 D215 W216 S219 T337 M338 H371 S372 R410 T422 D424 Q425 T590 T591 V592 S621 R628 Q660 R729 S733 V734 R828 S833 R884
Binding residue
(residue number reindexed from 1)		K10 K74 H137 D202 W203 S206 T324 M325 H354 S355 R378 T390 D392 Q393 T558 T559 V560 S587 R594 Q626 R690 S694 V695 R783 S788 R839
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000027 ribosomal large subunit assembly
GO:0051607 defense response to virus
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4qqx, PDBe:4qqx, PDBj:4qqx
PDBsum4qqx
PubMed25132177
UniProtQ47PJ0

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