Structure of PDB 4qlc Chain C Binding Site BS01

Receptor Information

>4qlc Chain C (length=104) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KSRSNRAGLQFPVGRIHRLLRKGNYAERVGAGAPVYLAAVMEYLAAEVLE
LAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLSGVTIAQGGVLPNIQAV
LLPK

Ligand information

>4qlc Chain I (length=166) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

actggccgccctggagaatcccggtgccgaggccgctcaattggtcgtag
acagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgtttta
accgccaaggggattactccctagtctccaggcacgtgtcagatatatac
atcctgtgcatgtaag

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4qlc Structural Mechanisms of Nucleosome Recognition by Linker Histones.
Resolution	3.503 Å
Binding residue (original residue number in PDB)	K14 R16 R28 R31 R76
Binding residue (residue number reindexed from 1)	K1 R3 R15 R18 R63
Binding affinity	PDBbind-CN: Kd=0.35uM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0030527	structural constituent of chromatin
GO:0031492	nucleosomal DNA binding
GO:0046982	protein heterodimerization activity

	Biological Process
GO:0006325	chromatin organization
GO:0006334	nucleosome assembly
GO:0007526	larval somatic muscle development
GO:0031507	heterochromatin formation

	Cellular Component
GO:0000786	nucleosome
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005700	polytene chromosome
GO:0005704	polytene chromosome band

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External links

PDB	RCSB:4qlc, PDBe:4qlc, PDBj:4qlc
PDBsum	4qlc
PubMed	26212454
UniProt	P84051\|H2A_DROME Histone H2A (Gene Name=His2A)

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