Structure of PDB 4qi2 Chain C Binding Site BS01
Receptor Information
>4qi2 Chain C (length=152) Species:
10090
(Mus musculus) [
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QNPQQLSSNLWAAVRARGCQFLGPAMQEEALKLVLLALEDGSALSRKVLV
LFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKVTKRDEDSSLMQLKEEF
RTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSIIDK
LQ
Ligand information
>4qi2 Chain G (length=19) [
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uguuuucugugaaaacgga
.<<<<<<...>>>>>>...
Receptor-Ligand Complex Structure
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PDB
4qi2
Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
W184 R188 F194 R219 K220 S238 K239 T240 Q247 Y250 R251 E262 D263 S264
Binding residue
(residue number reindexed from 1)
W11 R15 F21 R46 K47 S65 K66 T67 Q74 Y77 R78 E89 D90 S91
Binding affinity
PDBbind-CN
: Kd=119nM
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4qi2
,
PDBe:4qi2
,
PDBj:4qi2
PDBsum
4qi2
PubMed
25026077
UniProt
Q4VGL6
|RC3H1_MOUSE Roquin-1 (Gene Name=Rc3h1)
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