Structure of PDB 4pfq Chain C Binding Site BS01

Receptor Information

>4pfq Chain C (length=184) Species: 446465 (Brachybacterium faecium DSM 4810)

VPQTHPHPDVDRVLLDEQQIRDRLAELGEQIAADYAEEPPVLVGVLRGAV
MVMADLARQIDLKVEMDWMAVSSYGSGTKSSGVVRILKDLSGDITDRNVL
IVEDIIDSGLTLKWLLSNLRSRGPKSVEVAALLRKPDAARVDIDVKYIGF
DIPSEFVIGYGLDYAENYRNLPYVGVLSRSVYED

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 4pfq Chain C Residue 400

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4pfq Crystal structure of hypoxanthine phosphoribosyltransferase from Brachybacterium faecium DSM 4810, NYSGRC Target 0299763.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): E126 D127
• Binding residue (residue number reindexed from 1): E103 D104
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E126 D127 D130 F179 R192
• Catalytic site (residue number reindexed from 1): E103 D104 D107 F156 R169
• Enzyme Commision number: 2.4.2.8: hypoxanthine phosphoribosyltransferase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000287 magnesium ion binding
• GO:0004422 hypoxanthine phosphoribosyltransferase activity
• GO:0016757 glycosyltransferase activity
• GO:0046872 metal ion binding
• GO:0052657 guanine phosphoribosyltransferase activity

Biological Process

• GO:0006166 purine ribonucleoside salvage
• GO:0006178 guanine salvage
• GO:0032263 GMP salvage
• GO:0032264 IMP salvage
• GO:0046100 hypoxanthine metabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:4pfq, PDBe:4pfq, PDBj:4pfq
• PDBsum: 4pfq
• UniProt: C7MC15