Structure of PDB 4oau Chain C Binding Site BS01

Receptor Information
>4oau Chain C (length=692) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDI
VELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFY
GFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMD
AAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHL
LLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGK
TALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHG
AKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADT
SEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSE
SHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQE
LHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDL
GRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVR
DCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPEHSK
SFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGENIDEEK
HKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4oau Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		E55 E57 G58 W60 Q68 K89 Y124 F126 E131 Y135 R155
Binding residue
(residue number reindexed from 1)		E31 E33 G34 W36 Q44 K65 Y100 F102 E107 Y111 R131
Enzymatic activity
Enzyme Commision number 3.1.26.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004540 RNA nuclease activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019843 rRNA binding
GO:0043021 ribonucleoprotein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0043488 regulation of mRNA stability
GO:0045071 negative regulation of viral genome replication
GO:0045444 fat cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046326 positive regulation of D-glucose import
GO:0051607 defense response to virus
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol
GO:0016363 nuclear matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4oau, PDBe:4oau, PDBj:4oau
PDBsum4oau
PubMed24578532
UniProtQ05823|RN5A_HUMAN 2-5A-dependent ribonuclease (Gene Name=RNASEL)

[Back to BioLiP]