Structure of PDB 4num Chain C Binding Site BS01

Receptor Information
>4num Chain C (length=215) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGI
FIINPISGQLSVTKPLDRELIARFHLRSHAVDINGNQVENPMDIVINVID
MNDNRPEFLHQVWNGSVPEGSKPGTYVMTVTAIDADDPNALNGMLRYRIL
SQAPSTPSPNMFTINNETGDIITVAAGLDREKVQQYTLIIQATDMEGNPT
YGLSNTATAVITVTD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain4num Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4num Structural and energetic determinants of adhesive binding specificity in type I cadherins.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		N102 N104 D134 D136 N142 D194
Binding residue
(residue number reindexed from 1)		N102 N104 D134 D136 N142 D194
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4num, PDBe:4num, PDBj:4num
PDBsum4num
PubMed25253890
UniProtP15116|CADH2_MOUSE Cadherin-2 (Gene Name=Cdh2)

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