Structure of PDB 4mzr Chain C Binding Site BS01

Receptor Information

>4mzr Chain C (length=234) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SSSVPSQKTYQGSYGFRLGFLHSGTAKFGTCTYSPALNKMFVQLAKTVPV
QLYVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSSDSDGLAPPQH
LIRVEGNLRAEYLDDPNTFRHSVVVPYEPPEVGSDYTTIYFKFMCNSSCM
GGMNRRPILVIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENLRKKT
MDGEYFTLQIRGRERFEQFRERNEALELKDAQAT

Ligand information

>4mzr Chain K (length=26) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tgagacttgcccagacttgcccgttt

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4mzr Reversal of the DNA-Binding-Induced Loop L1 Conformational Switch in an Engineered Human p53 Protein.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	R273 A276 R280
Binding residue (residue number reindexed from 1)	R180 A183 R187
Binding affinity	PDBbind-CN: Kd=6.93nM

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process
GO:0051262	protein tetramerization

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:4mzr, PDBe:4mzr, PDBj:4mzr
PDBsum	4mzr
PubMed	24374182
UniProt	P04637\|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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