Structure of PDB 4m8l Chain C Binding Site BS01

Receptor Information
>4m8l Chain C (length=217) Species: 263 (Francisella tularensis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NQDELKKLAATEAAKSITTEITLGVGTGSTVGFLIEELVNYRDKIKTVVS
SSEDSTRKLKALGFDVVDLNYAGEIDLYIDGADECNNHKELIKGGGAALT
REKICVAAAKKFICIIDESKKVNTLGNFPLPIEVIPMARSYIARQIVKLG
GQPVYREQTITDNGNVILDVYNLKIDNPLKLETELNQITGVVTNGIFALK
PADTVIMATKDSNIVVL
Ligand information
Ligand ID5RP
InChIInChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5+/m1/s1
InChIKeyFNZLKVNUWIIPSJ-UHNVWZDZSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OCC(=O)[C@H](O)[C@H](O)CO[P](O)(O)=O
OpenEye OEToolkits 1.5.0C(C(C(C(=O)CO)O)O)OP(=O)(O)O
CACTVS 3.341OCC(=O)[CH](O)[CH](O)CO[P](O)(O)=O
ACDLabs 10.04O=P(O)(O)OCC(O)C(O)C(=O)CO
OpenEye OEToolkits 1.5.0C([C@H]([C@H](C(=O)CO)O)O)OP(=O)(O)O
FormulaC5 H11 O8 P
NameRIBULOSE-5-PHOSPHATE
ChEMBL
DrugBank
ZINCZINC000001532567
PDB chain4m8l Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4m8l crystal structure of RpiA-R5P complex
Resolution2.37 Å
Binding residue
(original residue number in PDB)		T34 G35 S36 T37 G88 A89 D90 K100 G101 G103 E109 K127
Binding residue
(residue number reindexed from 1)		T27 G28 S29 T30 G81 A82 D83 K93 G94 G96 E102 K120
Annotation score5
Enzymatic activity
Enzyme Commision number 5.3.1.6: ribose-5-phosphate isomerase.
Gene Ontology
Molecular Function
GO:0004751 ribose-5-phosphate isomerase activity
GO:0016853 isomerase activity
Biological Process
GO:0006014 D-ribose metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4m8l, PDBe:4m8l, PDBj:4m8l
PDBsum4m8l
PubMed
UniProtA4IYN5|RPIA_FRATW Ribose-5-phosphate isomerase A (Gene Name=rpiA)

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