Structure of PDB 4lkm Chain C Binding Site BS01
Receptor Information
>4lkm Chain C (length=216) Species:
9606
(Homo sapiens) [
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DCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPN
SLMKKITLLKYFRNYMSEHLLKAGANIARLPYLRTWFRTRSAIILHLSNG
SVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELAS
RLRYARTMVDKLLSSR
Ligand information
>4lkm Chain D (length=7) Species:
32630
(synthetic construct) [
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cPLHSTM
Receptor-Ligand Complex Structure
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PDB
4lkm
Exploring the binding nature of pyrrolidine pocket-dependent interactions in the polo-box domain of polo-like kinase 1
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
W414 V415 D416 Y417 Y485 H489 L490 L491 R516 H538 K540
Binding residue
(residue number reindexed from 1)
W44 V45 D46 Y47 Y115 H119 L120 L121 R138 H160 K162
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4lkm
,
PDBe:4lkm
,
PDBj:4lkm
PDBsum
4lkm
PubMed
24223211
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
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