Structure of PDB 4isr Chain C Binding Site BS01

Receptor Information
>4isr Chain C (length=413) Species: 1491 (Clostridium botulinum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INDSKILSLQNKKNTLMDTSGYNAEVRVEGNVQLNPIFPFDFKLGSSGDD
RGKVIVTQNENIVYNAMYESFSISFWIRINKWVSNLPGYTIIDSVKNNSG
WSIGIISNFLVFTLKQNENSEQDINFSYDISKNAAGYNKWFFVTITTNMM
GNMMIYINGKLIDTIKVKELTGINFSKTITFQMNKIPNDNINMWIRDFYI
FAKELDDKDINILFNSLQYTNVVKDYWGNDLRYDKEYYMINVNYMNRYMS
KKGNGIVFNTRKNNNDFNEGYKIIIKRIRGNTNDTRVRGENVLYFNTTID
NKQYSLGMYKPSRNLGTDLVPLGALDQPMDEIRKYGSFIIQPCNTFDYYA
SQLFLSSNATTNRLGILSIGSYSFKLGDDYWFNHEYLIPVIKIEHYASLL
ESTSTHWVFVPAS
Ligand information
>4isr Chain F (length=16) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SQEDMFAKLKDKFFNE
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4isr Crystal Structures of Botulinum Neurotoxin DC in Complex with Its Protein Receptors Synaptotagmin I and II.
Resolution2.59 Å
Binding residue
(original residue number in PDB)		M1179 Y1180 K1181 P1182 N1185 L1190 V1191 Y1206 L1235 E1265
Binding residue
(residue number reindexed from 1)		M308 Y309 K310 P311 N314 L319 V320 Y335 L364 E394
Enzymatic activity
Catalytic site (original residue number in PDB) K906 I969
Catalytic site (residue number reindexed from 1) K43 I106
Enzyme Commision number ?
Gene Ontology
Cellular Component
GO:0005576 extracellular region

View graph for
Cellular Component
External links
PDB RCSB:4isr, PDBe:4isr, PDBj:4isr
PDBsum4isr
PubMed23932591
UniProtQ9LBR1

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