Structure of PDB 4hqj Chain C Binding Site BS01

Receptor Information
>4hqj Chain C (length=987) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTT
PEWVKFCRQLFGGFSMLLWIGAILCFLAYGIQAATEEEPQNDNLYLGVVL
SAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEEVV
VGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENP
LETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAA
EIEHFIHIITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGL
LATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRM
TVAHMWSDNQIHEADTTENQSGVSFDKTSATWLALSRIAGLCNRAVFQAN
QENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYTKIVEIPFNSTN
KYQLSIHKNPNTAEPRHLLVMKGAPERILDRCSSILIHGKEQPLDEELKD
AFQNAYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPLDNLCFV
GLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISE
GNETVEDIAARLNIPVSQVNPRDAKACVVHGSDLKDMTSEQLDDILKYHT
EIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPASKKADIGVAMGI
AGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPE
ITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQP
RNPKTDKLVNEQLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGL
RVNWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTPFFVTIVVVQWADLVI
CKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGVALRMYPLKPT
WWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
Ligand information
>4hqj Chain E (length=29) Species: 9823 (Sus scrofa) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
FYYDYETVRNGGLIFAALAFIVGLIILLS
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4hqj Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state.
Resolution4.3 Å
Binding residue
(original residue number in PDB)		F949 E953 A959 Y963 P975 K977
Binding residue
(residue number reindexed from 1)		F920 E924 A930 Y934 P946 K948
Enzymatic activity
Catalytic site (original residue number in PDB) D710 D714
Catalytic site (residue number reindexed from 1) D681 D685
Enzyme Commision number 7.2.2.13: Na(+)/K(+)-exchanging ATPase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005391 P-type sodium:potassium-exchanging transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008556 P-type potassium transmembrane transporter activity
GO:0016887 ATP hydrolysis activity
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0046872 metal ion binding
GO:0051117 ATPase binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006883 intracellular sodium ion homeostasis
GO:0010248 establishment or maintenance of transmembrane electrochemical gradient
GO:0030007 intracellular potassium ion homeostasis
GO:0036376 sodium ion export across plasma membrane
GO:0055085 transmembrane transport
GO:0086009 membrane repolarization
GO:1902600 proton transmembrane transport
GO:1990573 potassium ion import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0005890 sodium:potassium-exchanging ATPase complex
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030424 axon
GO:0042383 sarcolemma
GO:0042470 melanosome
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hqj, PDBe:4hqj, PDBj:4hqj
PDBsum4hqj
PubMed24051246
UniProtP05024|AT1A1_PIG Sodium/potassium-transporting ATPase subunit alpha-1 (Gene Name=ATP1A1)

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