Structure of PDB 4hfc Chain C Binding Site BS01

Receptor Information
>4hfc Chain C (length=311) Species: 251221 (Gloeobacter violaceus PCC 7421) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VSPPPPIADEPLTVNTGIYLIECYSLDDKAETFKVNAFLSLSWKDRRLAF
DPVRSGVRVKTYEPEAIWIPEIRFVNVENARDADVVDISVSPDGTVQYLE
RFSARVLSPLDFRRYPFDSQTLHIYLIVRSVDTRNIVLAVDLEKVGKNDD
VFLTGWDIESFTAVVKPANFALEDRLESKLDYQLRISRQYFSYIPNIILP
MLFILFISWTAFWSTSYEANVTLVVSTLIAHIAANILVETNLPKTPYMTY
TGAIIFMIYLFYFVAVIEVTVQHYLKVESQPARAASITRASRIAFPVVFL
LANIILAFLFF
Ligand information
Ligand IDBRJ
InChIInChI=1S/C2H5BrO/c3-1-2-4/h4H,1-2H2
InChIKeyLDLCZOVUSADOIV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04BrCCO
CACTVS 3.341OCCBr
OpenEye OEToolkits 1.5.0C(CBr)O
FormulaC2 H5 Br O
Name2-BROMOETHANOL
ChEMBLCHEMBL468583
DrugBank
ZINCZINC000004978447
PDB chain4hfc Chain C Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4hfc Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		N239 E243
Binding residue
(residue number reindexed from 1)		N235 E239
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0005267 potassium channel activity
GO:0005272 sodium channel activity
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006814 sodium ion transport
GO:0034220 monoatomic ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4hfc, PDBe:4hfc, PDBj:4hfc
PDBsum4hfc
PubMed23591864
UniProtQ7NDN8|GLIC_GLOVI Proton-gated ion channel (Gene Name=glvI)

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