Structure of PDB 4hab Chain C Binding Site BS01
Receptor Information
>4hab Chain C (length=187) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
HLSDMLQQLHSVNASKEDIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFN
DSTRLILYNDGDSLQYIERDGTESYLTNSLMKKITLLKYFRNYMSEHLLK
AGANITPRELPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLVT
YIDEKRDFRTYRLSLLCKELASRLRYARTMVDKLLSS
Ligand information
>4hab Chain F (length=6) Species:
32630
(synthetic construct) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
PLHSTM
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
4hab
Development of cyclic peptomer inhibitors targeting the polo-box domain of polo-like kinase 1.
Resolution
2.65 Å
Binding residue
(original residue number in PDB)
W414 V415 D416 Y417 H489 L490 L491 R516 H538
Binding residue
(residue number reindexed from 1)
W27 V28 D29 Y30 H97 L98 L99 R118 H140
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:4hab
,
PDBe:4hab
,
PDBj:4hab
PDBsum
4hab
PubMed
23498919
UniProt
P53350
|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)
[
Back to BioLiP
]
