Structure of PDB 4gz3 Chain C Binding Site BS01

Receptor Information

>4gz3 Chain C (length=674) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AVRLYRKALEVFPEFAAAHSNLASVLQQQGKLQEALMHYKEAIRISPTFA
DAYSNMGNTLKEMQDVQGALQCYTRAIQINPAFADAHSNLASIHKDSGNI
PEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDYDERMKKLVSIVAD
QLEKNRLPSVHPHHSMLYPLSHGFRKAIAERHGNLCLDKINVLHKPPYEH
PKDLKLSDGRLRVGYVSSDFGNHPTSHLMQSIPGMHNPDKFEVFCYALSP
DDGTNFRVKVMAEANHFIDLSQIPCNGKAADRIHQDGIHILVNMNGYTKG
ARNELFALRPAPIQAMWLGYPGTSGALFMDYIITDQETSPAEVAEQYSEK
LAYMPHTFFIGDHANMFPHLKKKAVIDFKHIYDNRIVLNGIDLKAFLDSL
PDVKIVKMNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQIN
NKAATGEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANI
LKRVPNSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRR
GQLADVCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLG
CLELIAKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTM
ELERLYLQMWEHYAAGNKPDHMIK

Ligand information

>4gz3 Chain D (length=14) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

YPGGSTPVSSANMM

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4gz3 Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Resolution	1.9 Å
Binding residue (original residue number in PDB)	H496 H517 N557 P559 Y632 T633 K634 Q839 V895 P897
Binding residue (residue number reindexed from 1)	H161 H182 N222 P224 Y297 T298 K299 Q485 V541 P543

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:4gz3, PDBe:4gz3, PDBj:4gz3
PDBsum	4gz3
PubMed	23103939
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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