Structure of PDB 4fdg Chain C Binding Site BS01

Receptor Information
>4fdg Chain C (length=592) Species: 2287 (Saccharolobus solfataricus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIDYRDVFIEFLTTFKGNNNQNKYIERINELVAYRKKSLIIEFSDVLSFN
ENLAYEIINNTKIILPILEGALYDHILQLDPTYQRDIEKVHVRIVGIPRV
IELRKIRSTDIGKLITIDGILVKVTPVKERIYKATYKHIHPDCMQEFEWP
EDEEMPEVLEMPTICPKCGKPGQFRLIPEKTKLIDWQKAVIQERPEEVPS
GQLPRQLEIILEDDLVDSARPGDRVKVTGILDIKQDSPVKRGSRAVFDIY
MKVSSIEVSQKVLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYGH
WELKEALALALFGGVPKVLEDTRIRGDIHILIIGDPGTAKSQMLQFISRV
APRAVYTTGKGSTAAGLTAAVVREKGTGEYYLEAGALVLADGGIAVIDEI
DKMRDEDRVAIHEAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYIS
ERPVSDNINLPPTILSRFDLIFILKDQPGEQDRELANYILDVHSGKSTKN
IIDIDTLRKYIAYARKYVTPKITSEAKNLITDFFVEMRKKSSETPDSPIL
ITPRQLEALIRISEAYAKMALKAEVTREDAERAINIMRLFLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4fdg Chain C Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4fdg Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		H144 C171 C174
Binding residue
(residue number reindexed from 1)		H138 C165 C168
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0017116 single-stranded DNA helicase activity
GO:0042802 identical protein binding
Biological Process
GO:0006260 DNA replication
GO:0032508 DNA duplex unwinding
Cellular Component
GO:0042555 MCM complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4fdg, PDBe:4fdg, PDBj:4fdg
PDBsum4fdg
PubMed23361460
UniProtQ9UXG1|MCM_SACS2 Minichromosome maintenance protein MCM (Gene Name=MCM)

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