Structure of PDB 4esv Chain C Binding Site BS01

Receptor Information

>4esv Chain C (length=434) Species: 1422 (Geobacillus stearothermophilus)

RIPPQSIEAEQAVLGAVFLDPAALVPASEILIPEDFYRAAHQKIFHAMLR
VADRGEPVDLVTVTAELAASEQLEEIGGVSYLSELADAVPTAANVEYYAR
IVEEKSVLRRLIRTATSIAQDGYTREDEIDVLLDEADRKIMEVSQRKHSG
AFKNIKDILVQTYDNIEMLHNRDGEITGIPTGFTELDRMTSGFQRSDLII
VAARPSVGKTAFALNIAQNVATKTNENVAIFSLEMSAQQLVMRMLCAEGN
INAQNLRTGKLTPEDWGKLTMAMGSLSNAGIYIDDTPSIRVSDIRAKCRR
LKQESGLGMIVIDYLQLIQGSGRSKENRQQEVSEISRSLKALARELEVPV
IALSQLSRSVEQRQDKRPMMSDIRESGSIEQDADIVAFLYRDDYYNKDSE
NKNIIEIIIAKQRNGPVGTVQLAFIKEYNKFVNL

Ligand information

>4esv Chain V (length=14)

tttttttttttttt

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4esv The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): Q336 R365 R381 E382 G384
• Binding residue (residue number reindexed from 1): Q329 R358 R374 E375 G377

Enzymatic activity

• Enzyme Commision number: 3.6.4.12: DNA helicase.

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0004386 helicase activity
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016853 isomerase activity
• GO:0016887 ATP hydrolysis activity
• GO:0042802 identical protein binding

Biological Process

• GO:0006260 DNA replication
• GO:0006268 DNA unwinding involved in DNA replication
• GO:0006269 DNA replication, synthesis of primer

Cellular Component

• GO:0005829 cytosol
• GO:1990077 primosome complex

External links

• PDB: RCSB:4esv, PDBe:4esv, PDBj:4esv
• PDBsum: 4esv
• PubMed: 23022319
• UniProt: Q9X4C9|DNAB_GEOSE Replicative DNA helicase DnaB (Gene Name=dnaB)