Structure of PDB 4blb Chain C Binding Site BS01

Receptor Information
>4blb Chain C (length=725) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATG
DGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLI
AYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEP
YFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHM
NADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQP
SKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVAL
KSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGR
QTVDAALAAAQTNAAAPGLHAIYGECRRLYPDQPNPLQVTAIVKYDSFGP
DPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSG
FGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDHVSWHS
PLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWN
GQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIETDGSN
LSGVSAKCAWDDLPIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFT
YKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKMLED
ALPKEYSWPEKKLKVSIVEHHHHHH
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4blb Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y487 F495 D499 H500 V501 S502 W503 H504 N605 L606 S607 G608 V609 S610 E641
Binding residue
(residue number reindexed from 1)		Y482 F490 D494 H495 V496 S497 W498 H499 N600 L601 S602 G603 V604 S605 E630
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015144 carbohydrate transmembrane transporter activity
GO:1901982 maltose binding
Biological Process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0055085 transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4blb, PDBe:4blb, PDBj:4blb
PDBsum4blb
PubMed24311597
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q9UMX1|SUFU_HUMAN Suppressor of fused homolog (Gene Name=SUFU)

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