Structure of PDB 4bdn Chain C Binding Site BS01

Receptor Information
>4bdn Chain C (length=246) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSAPF
MTLGISILYRKGTPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYD
KMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLT
QIGGLIDSKGYGVGTPMGSPYRDKIGIAILQLQEEGKLHMMKEKWW
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain4bdn Chain C Residue 900 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4bdn Correlating Efficacy and Desensitization with Gluk2 Ligand-Binding Domain Movements.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y488 P516 A518 R523 G688 A689 T690 E738
Binding residue
(residue number reindexed from 1)		Y58 P83 A85 R90 G135 A136 T137 E185
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:4bdn, PDBe:4bdn, PDBj:4bdn
PDBsum4bdn
PubMed23720540
UniProtP42260|GRIK2_RAT Glutamate receptor ionotropic, kainate 2 (Gene Name=Grik2)

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