Structure of PDB 3zxd Chain C Binding Site BS01

Receptor Information

>3zxd Chain C (length=290) Species: 6396 (Eisenia fetida)

GYEQIEVDVVAVWKEGYVYENRGSTSVDQKITITKGMKNVNSETRTVTAT
HSIGSTISTGDAFEIGSVEVSYSHSHEESQVSMTETEVYESKVIEHTITI
PPTSKFTRWQLNADVGGADIEYMYLIDEVTPIGGTQSIPQVITSRAKIIV
GRQIILGKTEIRIKHAERKEYMTVVSRKSWPAATLGHSKLFKFVLYEDWG
GFRIKTLNTMYSGYEYAYSSDQGGIYFDQGTDNPKQRWAINKSLPLRHGD
VVTFMNKYFTRSGLCYDDGPATNVYCLDKREDKWILEVVG

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3zxd Chain C Residue 546

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3zxd Structures of Lysenin Reveal a Shared Evolutionary Origin for Pore-Forming Proteins and its Mode of Sphingomyelin Recognition.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): K249 D257
• Binding residue (residue number reindexed from 1): K242 D250
• Annotation score: 4

Gene Ontology

Molecular Function

• GO:0090729 toxin activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0031640 killing of cells of another organism
• GO:0035821 modulation of process of another organism
• GO:0042742 defense response to bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0016020 membrane
• GO:0044218 other organism cell membrane

External links

• PDB: RCSB:3zxd, PDBe:3zxd, PDBj:3zxd
• PDBsum: 3zxd
• PubMed: 22819216
• UniProt: O18423|TXL_EISFE Lysenin