Structure of PDB 3wty Chain C Binding Site BS01

Receptor Information

>3wty Chain C (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PVIPAAALAGYTGSPPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDP
DEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDL
QSLLGYTPEELHAMLDVK

Ligand information

>3wty Chain D (length=15) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gaagccacatcctct

Receptor-Ligand Complex Structure

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PDB	3wty A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	Q336 L337 W375 K379 K383 M384 K388 R391 Y396 K399
Binding residue (residue number reindexed from 1)	Q18 L19 W57 K61 K65 M66 K70 R73 Y78 K81

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003700	DNA-binding transcription factor activity
GO:0043565	sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II

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Molecular Function

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Biological Process

External links

PDB	RCSB:3wty, PDBe:3wty, PDBj:3wty
PDBsum	3wty
PubMed	25083921
UniProt	P14921\|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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