Structure of PDB 3wts Chain C Binding Site BS01

Receptor Information
>3wts Chain C (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDP
DEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDL
QSLLGYTPEELHAMLDVK
Ligand information
Receptor-Ligand Complex Structure
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PDB3wts A novel allosteric mechanism on protein-DNA interactions underlying the phosphorylation-dependent regulation of Ets1 target gene expressions.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		Q336 L337 W375 K379 K383 M384 K388 Y396
Binding residue
(residue number reindexed from 1)		Q18 L19 W57 K61 K65 M66 K70 Y78
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:3wts, PDBe:3wts, PDBj:3wts
PDBsum3wts
PubMed25083921
UniProtP14921|ETS1_HUMAN Protein C-ets-1 (Gene Name=ETS1)

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