Structure of PDB 3w6x Chain C Binding Site BS01

Receptor Information
>3w6x Chain C (length=225) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIEWKLTANLRNGPTFFQPLADSIEPLQFKLIGSDTVATAFPVFDTKYIP
DSLINYLFKLFNLEIESGKTYPQLHSLTKQGFLNYWFHSFAVVVLQTDEK
FIQDNQDWNSVLLGTFYIKPNYAPRCSHNCNAGFLVNGAHRGQKVGYRLA
QVYLNWAPLLGYKYSIFNLVFVTNQASWKIWDKLNFQRIGLVPHAGILNG
FSEPVDAIIYGKDLTKIEPEFLSME
Ligand information
Ligand IDHZP
InChIInChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4-/m0/s1
InChIKeyPMMYEEVYMWASQN-IMJSIDKUSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O[C@@H]1CN[C@@H](C1)C(O)=O
OpenEye OEToolkits 1.5.0C1C(CNC1C(=O)O)O
CACTVS 3.341O[CH]1CN[CH](C1)C(O)=O
OpenEye OEToolkits 1.5.0C1[C@@H](CN[C@@H]1C(=O)O)O
ACDLabs 10.04O=C(O)C1NCC(O)C1
FormulaC5 H9 N O3
Name(4S)-4-hydroxy-L-proline
ChEMBLCHEMBL1233477
DrugBank
ZINCZINC000000901736
PDB chain3w6x Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3w6x Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism
Resolution2.299 Å
Binding residue
(original residue number in PDB)		Y75 N135 A136 F171 N172 L173
Binding residue
(residue number reindexed from 1)		Y71 N131 A132 F167 N168 L169
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.271: L-glutamate-5-semialdehyde N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046941 azetidine-2-carboxylic acid acetyltransferase activity
Biological Process
GO:0006526 L-arginine biosynthetic process
GO:0006562 proline catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3w6x, PDBe:3w6x, PDBj:3w6x
PDBsum3w6x
PubMed23818613
UniProtE9P8D2|MPR1_YEASX N-acetyltransferase MPR1 (Gene Name=MPR1)

[Back to BioLiP]