Structure of PDB 3qid Chain C Binding Site BS01

Receptor Information

>3qid Chain C (length=492) Species: 223997 (Murine norovirus 1)

RPSGTYAGLPIADYGDAPPLSTKTMFWRTSPEKLPPGAWEPAYLGSKDER
VDGPSLQQVMRDQLKPYSEPRGLLPPQEILDAVCDAIENRLENTLEPQKP
WTFKKACESLDKNTSSGYPYHKQKSKDWTGSAFIGDLGDQATHANNMYEM
GKSMRPIYTAALKDELVKPDKIYGKIKKRLLWGSDLGTMIRAARAFGPFC
DALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYTRWDSTQQRA
ILKRAGDIMVRLSPEPDLARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCP
CTTQLNSLAHWILTLCAMVEVTRVDPDIVMQESEFSFYGDDEVVSTNLEL
DMVKYTMALRRYGLLPTRADKEEGPLERRQTLQGISFLRRAIVGDQFGWY
GRLDRASIDRQLLWTKGPNHQNPFETLPGHAQRPSQLMALLGEAAMHGEK
YYRTVASRVSKEAAQSGIEMVVPRHRSVLRWVRFGTMDAETP

Ligand information

• Ligand ID: MN3
• InChI: InChI=1S/Mn/q+3
• InChIKey: MMIPFLVOWGHZQD-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Mn+3]
• Formula: Mn
• Name: MANGANESE (III) ION
• PDB chain: 3qid Chain C Residue 527

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3qid Crystal structures of murine norovirus-1 RNA-dependent RNA polymerase.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): D243 D347
• Binding residue (residue number reindexed from 1): D237 D341
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.4.22.66: calicivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:3qid, PDBe:3qid, PDBj:3qid
• PDBsum: 3qid
• PubMed: 21471315
• UniProt: Q80J95|POLG_MNV1 Genome polyprotein (Gene Name=ORF1)