Structure of PDB 3osl Chain C Binding Site BS01

Receptor Information
>3osl Chain C (length=296) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SYYEQYHSLNEIYSWIEVMTERYPDMVEKIHIGSSYEKYPLYVLKVSKKN
AMWIDCGIHAREWISPAFCLWFVGSVTYYYGKNLLKHMDFYIMPVVNVDG
YDYTWKKDRMWRKNRSLHEKNACVGTDLNRNFASKHWCGEGASSSSCSEI
YCGTYPESEPEVKAVADFLRRNIKHIKAYISMHSYSQKIVFPYSYSRSRS
KDHEELSLVAREAVFAMENIHRNIRYTHGSGSESLYLAPGGSDDWIYDLG
IKYSFTFELRDKGKYGFLLPESYIRPTCSEALVAVAKIASHVVKNV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3osl Chain C Residue 999 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3osl Flexibility of the Thrombin-activatable Fibrinolysis Inhibitor Pro-domain Enables Productive Binding of Protein Substrates.
Resolution6.0 Å
Binding residue
(original residue number in PDB)		H181 E184 H310
Binding residue
(residue number reindexed from 1)		H59 E62 H183
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H181 E184 R239 H310 E385
Catalytic site (residue number reindexed from 1) H59 E62 R112 H183 E258
Enzyme Commision number 3.4.17.20: carboxypeptidase U.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0042730 fibrinolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3osl, PDBe:3osl, PDBj:3osl
PDBsum3osl
PubMed20880845
UniProtQ2KIG3|CBPB2_BOVIN Carboxypeptidase B2 (Gene Name=CPB2)

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