Structure of PDB 3nmx Chain C Binding Site BS01

Receptor Information

>3nmx Chain C (length=323) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HHHMLHLLEQIRAYCETCWEWQEAHAPVEHQICPAVCVLMKLSFDEEHRH
AMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVA
NKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLR
EVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALA
FLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQT
LLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSK
HKMIAMGSAAALRNLMANRPAKY

Ligand information

>3nmx Chain E (length=13) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GGGEQLAINELIS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3nmx Structural basis for the recognition of Asef by adenomatous polyposis coli.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	C451 K455 F458
Binding residue (residue number reindexed from 1)	C37 K41 F44

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0008013	beta-catenin binding

	Biological Process
GO:0030178	negative regulation of Wnt signaling pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:3nmx, PDBe:3nmx, PDBj:3nmx
PDBsum	3nmx
PubMed	21788986
UniProt	P25054\|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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