Structure of PDB 3n96 Chain C Binding Site BS01

Receptor Information

>3n96 Chain C (length=467) Species: 9606,83333

KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFAALLHSLLEANCSLALAEELLLDGWGPP
PYSYCNTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLE
NGTWASKINYSQCEPIL

Ligand information

>3n96 Chain E (length=16) Species: 9606 (Homo sapiens)

SQRERAEQNRIIFDSV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3n96 Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
• Resolution: 2.75 Å
• Binding residue (original residue number in PDB): Q-321 Q46 I47 F68 N69 V71 Y73 K92 I93 Y95 P100 L102
• Binding residue (residue number reindexed from 1): Q49 Q411 I412 F433 N434 V436 Y438 K457 I458 Y460 P465 L467

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0015144 carbohydrate transmembrane transporter activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway
• GO:0008643 carbohydrate transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:3n96, PDBe:3n96, PDBj:3n96
• PDBsum: 3n96
• UniProt: P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
  Q13324|CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (Gene Name=CRHR2)