Structure of PDB 3n95 Chain C Binding Site BS01

Receptor Information
>3n95 Chain C (length=462) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTNAAAEFAALLHSLLEANCSLALAEELLLDGYSYC
NTTLDQIGTCWPRSAAGALVERPCPEYFNGVKYNTTRNAYRECLENGTWA
SKINYSQCEPIL
Ligand information
Receptor-Ligand Complex Structure
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PDB3n95 Structural basis of ligand selectivity in human CRFR1 and CRFR2 alpha extracellular domain
Resolution2.72 Å
Binding residue
(original residue number in PDB)		E-325 A-318 Q46 F68 N69 V71 Y73 I93
Binding residue
(residue number reindexed from 1)		E45 A52 Q406 F428 N429 V431 Y433 I453
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0015144 carbohydrate transmembrane transporter activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3n95, PDBe:3n95, PDBj:3n95
PDBsum3n95
PubMed
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
Q13324|CRFR2_HUMAN Corticotropin-releasing factor receptor 2 (Gene Name=CRHR2)

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