Structure of PDB 3mu6 Chain C Binding Site BS01

Receptor Information
>3mu6 Chain C (length=71) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSS
NKLFQYASTDMDKVLLKYTAY
Ligand information
Receptor-Ligand Complex Structure
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PDB3mu6 Inhibition of the function of class IIa HDACs by blocking their interaction with MEF2.
Resolution2.434 Å
Binding residue
(original residue number in PDB)		G2 R3 K4 I6 K23 R24 K30
Binding residue
(residue number reindexed from 1)		G1 R2 K3 I5 K22 R23 K29
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0045944 positive regulation of transcription by RNA polymerase II

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Molecular Function
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Biological Process
External links
PDB RCSB:3mu6, PDBe:3mu6, PDBj:3mu6
PDBsum3mu6
PubMed22396528
UniProtQ02078|MEF2A_HUMAN Myocyte-specific enhancer factor 2A (Gene Name=MEF2A)

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