Structure of PDB 3kze Chain C Binding Site BS01

Receptor Information
>3kze Chain C (length=87) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGKVTHSIHIEKSDADTYGFSLSSVEGIRRLYVNSVKETGLASKKGLKAG
DEILEINNRAADALNSSMLKDFLSQPSLGLLVRTYPE
Ligand information
Receptor-Ligand Complex Structure
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PDB3kze The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		T857 Y858 F860 S861 L862 S863 S864 N876 S908 L915
Binding residue
(residue number reindexed from 1)		T17 Y18 F20 S21 L22 S23 S24 N34 S66 L73
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
Biological Process
GO:0007264 small GTPase-mediated signal transduction
GO:0090630 activation of GTPase activity

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Molecular Function
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Biological Process
External links
PDB RCSB:3kze, PDBe:3kze, PDBj:3kze
PDBsum3kze
PubMed20361982
UniProtQ13009|TIAM1_HUMAN Rho guanine nucleotide exchange factor TIAM1 (Gene Name=TIAM1)

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