Structure of PDB 3k23 Chain C Binding Site BS01
Receptor Information
>3k23 Chain C (length=246) Species:
9606
(Homo sapiens) [
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LPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAA
VKWAKAIPGFRNLHLDDQMTLLQYSWMYLMAFALGWRSYRQSSANLLCFA
PDLIINEQRMTLPGMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSS
VPKDGLKQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSM
HEVVENLLNYCFQTFLDKTMIEFPEMLAEIITNQIPKYNIKKLLFH
Ligand information
>3k23 Chain F (length=10) Species:
9606
(Homo sapiens) [
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ENALLRYLLD
Receptor-Ligand Complex Structure
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PDB
3k23
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor.
Resolution
3.0 Å
Binding residue
(original residue number in PDB)
K579 M593 Q597 E751 M752 E755 N759
Binding residue
(residue number reindexed from 1)
K55 M69 Q73 E225 M226 E229 N233
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3k23
,
PDBe:3k23
,
PDBj:3k23
PDBsum
3k23
PubMed
19822747
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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