Structure of PDB 3jcs Chain C Binding Site BS01

Receptor Information
>3jcs Chain C (length=301) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSVSVYSASSDSVVGTCPLPAVFTAPIRNDIVKFVHTNMAKNSRQAYAVN
RLSGMNHSAHSWGTGRAVARIPRISGGGTSTSGAGAFGNMCRGGRMFAPT
KIFRRWHRKINLHQKRFAVVSALAASSVPSLVMSRGHRIDNVPEVPLVVE
DSIQGYEKTKEAMAFLKAIAAIDDVNRVNDSREIRAGRGKMRNRRYVARR
GPMLVMPNNKGTRAFRNIFGLDLANVSALNLLHLAPGGHVGRFVIWTKSA
FEQLDKIFGTFTEASAVKKGFTLPAPMLTNTDVTRIMQSEEVRRVLKPKK
L
Ligand information
>3jcs Chain 1 (length=1554) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacuguauuaag
cgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucug
ccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugag
cgaaaguuugaaaagcacuuuggaaagagagugaaauagaaccugaaguc
gugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccu
acugcauuauccugucggccggcgggcaacgaagugcaagaauuuugggu
cuuggugaaugcuccauggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggagauauccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccgggaacccagguggaggccuguagcgaugcugacgugcaaa
ucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuag
uagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaag
uauugugcgguaaagcaugauuagagguugguguuaauaucgaccuauuc
ucacuuuaaaugugcaaacaaaccugccuuagccugcaaggccggaaaga
aauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugcg
gaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucga
uacgugaaaaggguguugguggauaacaaauccaccggccccgaaaaugg
augacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggc
ggaaacuuggagaaaguguagcccuuccgauguagauguggccuggaggu
uaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcag
aucuugguuggcguagcaaagaucuaacggagacguuggauacuggagcg
gggaaggauuucgugccaacggcacucguacacgaguuguucggaaacug
agcacaacguuauaucguuuuguuaggaaagugaaggugugggccauaac
ugaaaaggggcaacagagaaccuggguuauauuccaaaaagaaauugcau
gugg
......................<<<<<......<<....>>.......>>
>>.>...<.....<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>
....<..<<.<<<<.<...<<<<..<<.<<<<<.......<.........
.<......<..........>.....>..........>............<
<.......>>.....>>>>>...>>....>>>>.>.>>>>.>>.>.....
......<<<<<<<........>>>>>>>......<<<<<........>>>
>>..>>>....>...............................<<....>
>................<<<<....>>>>.....................
.............<<<..<<<<<<.<<<<<.......<....<.<<....
..........<<<..........>>>.................>>.>...
.....<....>.......>......>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<.<<<<.<<<...>>
>>>.>>>>>...<<....>>.....<.....>.....<<<.......<..
..........>........>>>..<<<<<<<.<.......>.>>>>>.>>
....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<..>>>.>>>.....>>>...<<<..<<.<<........
>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...
...>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.
<.<<<<<<<...<<<..<<<....<<<<<<<<<<..>>>>>>>>>>....
>>>>>>....>>>>>>>.....<<.<<<...<<..>>..>>>.>>.....
.>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<
<..[...>>>>..<<<<<<<...<<<(((........<<<<<......<.
...]......<<...<<<<<<<<<.....>>>>>>>>>..>>........
..))).>....>>>>>..........>>>...>>>>>>><<<<.<<<<<.
.....................>>>>>>>>>....>>>>>....<<<<<<<
<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>......
..>>>>>>..............<<<<<<<....>>>>>>>..........
..........<<<<<....<<.....>>..>>>>>....<<.........
.<<.<<<<<......>>>>...............<<<<.......>>..>
>......>.>>..........<<<..........>....>>.>>......
....
Receptor-Ligand Complex Structure
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PDB3jcs 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Resolution2.8 Å
Binding residue
(original residue number in PDB)
R32 D34 I35 K37 F38 T41 M43 A44 K45 N46 R48 Q49 Y51 V53 N54 S57 G58 M59 N60 H61 S62 S65 T68 A71 V72 A73 R74 I75 P76 S79 G81 G82 T83 S84 T85 A88 G89 N93 M94 C95 R96 G97 R99 M100 F101 A102 P103 K105 F107 R108 R109 K113 N115 L116 H117 Q118 K119 R120 R139 K162 T163 M167 R181 R186 I188 R189 A190 G191 R192 K194 R196 N197 R198 Y200 R203 R204 R217 N221 F223 A232 N234 P240 G241 H243 V271 K272 K273
Binding residue
(residue number reindexed from 1)
R28 D30 I31 K33 F34 T37 M39 A40 K41 N42 R44 Q45 Y47 V49 N50 S53 G54 M55 N56 H57 S58 S61 T64 A67 V68 A69 R70 I71 P72 S75 G77 G78 T79 S80 T81 A84 G85 N89 M90 C91 R92 G93 R95 M96 F97 A98 P99 K101 F103 R104 R105 K109 N111 L112 H113 Q114 K115 R116 R135 K158 T159 M163 R177 R182 I184 R185 A186 G187 R188 K190 R192 N193 R194 Y196 R199 R200 R213 N217 F219 A228 N230 P236 G237 H239 V267 K268 K269
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component
External links
PDB RCSB:3jcs, PDBe:3jcs, PDBj:3jcs
PDBsum3jcs
PubMed27373148
UniProtA0A3S5H7L0

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