Structure of PDB 3gdv Chain C Binding Site BS01

Receptor Information
>3gdv Chain C (length=294) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ETPASYNLAVRRAAPAVVNVYNRGLNQLEIRTLGSGVIMDQRGYIITNKH
VINDADQIIVALQDGRVFEALLVGSDSLTDLAVLKINATGGLPTIPINAR
RVPHIGDVVLAIGNPYNLGQTITQGIISATGRIGNPTGRQNFLQTDASIN
PGNSGGALVNSLGELMGINTLSFDKETPEGIGFAIPFQLATKIMDKLIRD
GRVIRGYIGIGGREIAPQLQGIVVNEVSPDGPAANAGIQVNDLIISVDNK
PAISALETMAQVAEIRPGSVIPVVVMRDDKQLTLQVTIQEYPAT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3gdv OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism.
Resolution2.489 Å
Binding residue
(original residue number in PDB)		Y258 I259 G260 I261 G262 G263 L316 M319
Binding residue
(residue number reindexed from 1)		Y207 I208 G209 I210 G211 G212 L256 M259
Enzymatic activity
Enzyme Commision number 3.4.21.107: peptidase Do.
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008236 serine-type peptidase activity
GO:0042802 identical protein binding
Biological Process
GO:0006508 proteolysis
GO:0071218 cellular response to misfolded protein
Cellular Component
GO:0005886 plasma membrane
GO:0030288 outer membrane-bounded periplasmic space

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3gdv, PDBe:3gdv, PDBj:3gdv
PDBsum3gdv
PubMed19836340
UniProtP0AEE3|DEGS_ECOLI Serine endoprotease DegS (Gene Name=degS)

[Back to BioLiP]