Structure of PDB 3eyd Chain C Binding Site BS01

Receptor Information
>3eyd Chain C (length=151) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VEGEVQIVSTATQTFLATCINGVCWTVYHGAGTRTIASPKGPVIQMYTNV
DQDLVGWPAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLS
PRPISYLKGSSGGPLLCPAGHAVGLFRAAVCTRGVAKAVDFIPVENLETT
M
Ligand information
>3eyd Chain B (length=22) Species: 11104 (Hepatitis C virus (isolate 1)) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
KGSVVIVGRIVLSGKPAIIPKK
Receptor-Ligand Complex Structure
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PDB3eyd Potent inhibitors of HCV-NS3 protease derived from boronic acids.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		A111 V113
Binding residue
(residue number reindexed from 1)		A83 V85
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D81 G137 S139
Catalytic site (residue number reindexed from 1) H29 D53 G109 S111
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3eyd, PDBe:3eyd, PDBj:3eyd
PDBsum3eyd
PubMed19022670
UniProtP26664|POLG_HCV1 Genome polyprotein

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