Structure of PDB 3edr Chain C Binding Site BS01
Receptor Information
>3edr Chain C (length=145) Species:
9606
(Homo sapiens) [
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RDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCF
RSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIY
GKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQ
Ligand information
>3edr Chain F (length=5) Species:
559292
(Saccharomyces cerevisiae S288C) [
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LDESD
Receptor-Ligand Complex Structure
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PDB
3edr
Structural basis for executioner caspase recognition of P5 position in substrates.
Resolution
2.45 Å
Binding residue
(original residue number in PDB)
R387 H444 Q484 C486
Binding residue
(residue number reindexed from 1)
R36 H93 Q133 C135
Enzymatic activity
Catalytic site (original residue number in PDB)
G385 V386 H444 G445 C486
Catalytic site (residue number reindexed from 1)
G34 V35 H93 G94 C135
Enzyme Commision number
3.4.22.60
: caspase-7.
Gene Ontology
Molecular Function
GO:0004197
cysteine-type endopeptidase activity
GO:0008234
cysteine-type peptidase activity
Biological Process
GO:0006508
proteolysis
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Molecular Function
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Biological Process
External links
PDB
RCSB:3edr
,
PDBe:3edr
,
PDBj:3edr
PDBsum
3edr
PubMed
18780184
UniProt
P55210
|CASP7_HUMAN Caspase-7 (Gene Name=CASP7)
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