Structure of PDB 3ed1 Chain C Binding Site BS01

Receptor Information
>3ed1 Chain C (length=301) Species: 39947 (Oryza sativa Japonica Group) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VPLHTWVLISNFKLSYNILRRADGTFERDLGEYLDRRVPANARPLEGVSS
FDHIIDQSVGLEVRIYRAFPVIIFFHGGSFVHSSASSTIYDSLCRRFVKL
SKGVVVSVNYRRAPEHRYPCAYDDGWTALKWVMSQPFMRARVFLSGDSSG
GNIAHHVAVRAADEGVKVCGNILLNAMFGGTERTESERRLDGKYFVTLQD
RDWYWKAYLPEDADRDHPACNPFGPNGRRLGGLPFAKSLIIVSGLDLTCD
RQLAYADALREDGHHVKVVQCENATVGFYLLPNTVHYHEVMEEISDFLNA
N
Ligand information
Ligand IDGA3
InChIInChI=1S/C19H22O6/c1-9-7-17-8-18(9,24)5-3-10(17)19-6-4-11(20)16(2,15(23)25-19)13(19)12(17)14(21)22/h4,6,10-13,20,24H,1,3,5,7-8H2,2H3,(H,21,22)/t10-,11+,12-,13-,16-,17+,18+,19-/m1/s1
InChIKeyIXORZMNAPKEEDV-OBDJNFEBSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[C@]12[C@@H](O)C=C[C@@]3(OC1=O)[C@@H]4CC[C@]5(O)C[C@]4(CC5=C)[C@H]([C@H]23)C(O)=O
OpenEye OEToolkits 1.5.0CC12C(C=CC3(C1C(C45C3CCC(C4)(C(=C)C5)O)C(=O)O)OC2=O)O
OpenEye OEToolkits 1.5.0C[C@@]12[C@H](C=C[C@@]3([C@@H]1[C@@H]([C@]45[C@H]3CC[C@](C4)(C(=C)C5)O)C(=O)O)OC2=O)O
CACTVS 3.341C[C]12[CH](O)C=C[C]3(OC1=O)[CH]4CC[C]5(O)C[C]4(CC5=C)[CH]([CH]23)C(O)=O
ACDLabs 10.04O=C(O)C5C21CC(O)(\C(=C)C1)CCC2C34OC(=O)C(C)(C(O)C=C3)C45
FormulaC19 H22 O6
NameGIBBERELLIN A3;
(1S,2S,4aR,4bR,7S,9aS,10S,10aR)-2,7-dihydroxy-1-methyl-8-methylidene-13-oxo-1,2,4b,5,6,7,8,9,10,10a-decahydro-4a,1-(epo xymethano)-7,9a-methanobenzo[a]azulene-10-carboxylic acid
ChEMBLCHEMBL1232952
DrugBankDB07814
ZINCZINC000003860467
PDB chain3ed1 Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ed1 Structural basis for gibberellin recognition by its receptor GID1.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		F27 G122 S123 I133 Y134 S198 V246 D250 R251 Y254 G327
Binding residue
(residue number reindexed from 1)		F12 G78 S79 I89 Y90 S148 V196 D200 R201 Y204 G277
Annotation score4
Enzymatic activity
Enzyme Commision number 3.-.-.-
Gene Ontology
Molecular Function
GO:0010331 gibberellin binding
GO:0016787 hydrolase activity
Biological Process
GO:0009739 response to gibberellin
GO:0009740 gibberellic acid mediated signaling pathway
GO:0009939 positive regulation of gibberellic acid mediated signaling pathway
GO:0010325 raffinose family oligosaccharide biosynthetic process
GO:0048444 floral organ morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ed1, PDBe:3ed1, PDBj:3ed1
PDBsum3ed1
PubMed19037316
UniProtQ6L545|GID1_ORYSJ Gibberellin receptor GID1 (Gene Name=GID1)

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