Structure of PDB 3dxe Chain C Binding Site BS01

Receptor Information
>3dxe Chain C (length=130) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVA
PATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHM
FWCEPNAASLSEAVQAACMLRYQKCLDARS
Ligand information
>3dxe Chain D (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VAPEERHLSKMQQNGYENPTYKFFEQM
Receptor-Ligand Complex Structure
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PDB3dxe Structure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		V559 R607 L609 S610 F611 L612 A613 V614 G615 R616 A644 E648 Q651 C654 M655 Y658 C661 L662 R665
Binding residue
(residue number reindexed from 1)		V23 R71 L73 S74 F75 L76 A77 V78 G79 R80 A108 E112 Q115 C118 M119 Y122 C125 L126 R129
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001540 amyloid-beta binding

View graph for
Molecular Function
External links
PDB RCSB:3dxe, PDBe:3dxe, PDBj:3dxe
PDBsum3dxe
PubMed18833287
UniProtO00213|APBB1_HUMAN Amyloid beta precursor protein binding family B member 1 (Gene Name=APBB1)

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