Structure of PDB 3dgv Chain C Binding Site BS01

Receptor Information
>3dgv Chain C (length=379) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QRGQVRTSRQVQILQNVTTTYKIVLWQPVAAEYEVHFFVNASDVSNVKAH
LNASIPFRVLVENVEDLIRQQTSSPRASSSYYEQYHSLNEIYSWIEVMTE
RYPDMVEKIHIGSSYEKYPLYVLKVSKKEKNAMWIDCGIHAREWISPAFC
LWFVGSVTYYYGKEKMHTNLLKHMDFYIMPVVNVDGYDYTWKKDRMWRKN
RSLHEKNACVGTDLNRNFASKHWCGEGASSSSCSEIYCGTYPESEPEVKA
VADFLRRNIKHIKAYISMHSYSQKIVFPYSYSRSRSKDHEELSLVAREAV
FAMENIHRNTHGSGSESLYLAPGGSDDWIYDLGIKYSFTFELRDKGKYGF
LLPESYIRPTCSEALVAVAKIASHVVKNV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3dgv Chain C Residue 310 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3dgv The crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) provides the structural basis for its intrinsic activity and the short half-life of TAFIa.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H69 E72 H196
Binding residue
(residue number reindexed from 1)		H140 E143 H269
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H140 E143 R198 H269 E341
Enzyme Commision number 3.4.17.20: carboxypeptidase U.
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
GO:0042730 fibrinolysis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3dgv, PDBe:3dgv, PDBj:3dgv
PDBsum3dgv
PubMed18669641
UniProtQ2KIG3|CBPB2_BOVIN Carboxypeptidase B2 (Gene Name=CPB2)

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