Structure of PDB 3c5i Chain C Binding Site BS01

Receptor Information

>3c5i Chain C (length=353) Species: 5850 (Plasmodium knowlesi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DLTDPLYIKKICLEKVPEWNHFTEDNLRVKQITNQLFEVGLKEETANNYN
SIRTRVLFRIYGKHVDELYNTISEFEVYKTMSKYKIAPQLLNTFNGGRIE
EWLYGDPLRIDDLKNPTILIGIANVLGKFHTLSRKRHLPEHWDRTPCIFK
MMEKWKNQLFKYKNIEKYNCDIHKYIKESDKFIKFMKVYSKSDNLANTIV
FCHNDLQENNIINTNKCLRLIDFEYSGFNFLATDIANFFIETSIDYSVSS
YPFFEIDKKKYISYENRKLFITAYLSNYLDLVVPTPKLIDEILEAVEVQA
LGAHLLWGFWSIIRGYQTKYNEFDFFLYAEQRLKMYDDQKEYLISNNIIK
GYD

Ligand information

>3c5i Chain E (length=5) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NLYFQ

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3c5i Crystal structure of Plasmodium knowlesi choline kinase, PKH_134520.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	K180 Y181 Y264
Binding residue (residue number reindexed from 1)	K167 Y168 Y251

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0004103	choline kinase activity
GO:0004305	ethanolamine kinase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:3c5i, PDBe:3c5i, PDBj:3c5i
PDBsum	3c5i
PubMed
UniProt	D0VWT1

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