Structure of PDB 2xkp Chain C Binding Site BS01

Receptor Information
>2xkp Chain C (length=196) Species: 1140 (Synechococcus elongatus PCC 7942 = FACHB-805) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PLQIEQFERGKTIFFPGDPAERVYLLVKGAVKLSRVYESGEEITVALLRE
NSVFGVLSLLRSDRFYHAVAFTPVQLFSVPIEFMQKALIERPELANVMLQ
GLSSRILQTEMMIETLAHRDMGSRLVSFLLILCRDFGIPSPDGITIDLKL
SHQAIAEAIGSTRVTVTRLLGDLRESKLIAIHKKRITVFNPVALSQ
Ligand information
Ligand IDAKG
InChIInChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)
InChIKeyKPGXRSRHYNQIFN-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(=O)CCC(=O)O
OpenEye OEToolkits 1.7.6C(CC(=O)O)C(=O)C(=O)O
CACTVS 3.385OC(=O)CCC(=O)C(O)=O
FormulaC5 H6 O5
Name2-OXOGLUTARIC ACID
ChEMBLCHEMBL1686
DrugBankDB08845
ZINCZINC000001532519
PDB chain2xkp Chain C Residue 1220 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2xkp Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		F74 G75 V76 L77 R87 Y89 R128
Binding residue
(residue number reindexed from 1)		F54 G55 V56 L57 R64 Y66 R105
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2xkp, PDBe:2xkp, PDBj:2xkp
PDBsum2xkp
PubMed20716687
UniProtP29283|NTCA_SYNE7 Global nitrogen regulator (Gene Name=ntcA)

[Back to BioLiP]