Structure of PDB 2woo Chain C Binding Site BS01

Receptor Information

>2woo Chain C (length=303) Species: 4896 (Schizosaccharomyces pombe)

PGTLENLLEQTSLKWIFVGGKGGVGKTTTSCSLAIQMSKVRSSVLLISTD
PAHNLSDAFGTKFGKDARKVPGFDNLSAMEIDPNLSIQEMTEQALSGMMQ
DLAFTIPGIDEALAFAEILKQIKSMEFDCVIFDTAPTGHTLRFLNFPTVL
EKALGKLGGLSSRFGPMINQMGSIMGQDLFGKMESMRANISEVNKQFKNP
DLTTFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLLLDPNTTCP
QCMARRKMQQKYLAQIEELYEDFHVVKVPQVPAEVRGTEALKSFSEMLVK
PYV

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 2woo Chain C Residue 1323

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2woo The Structural Basis of Tail-Anchored Membrane Protein Recognition by Get3.
• Resolution: 3.006 Å
• Binding residue (original residue number in PDB): C268 C271
• Binding residue (residue number reindexed from 1): C249 C252
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): G29 G31 K32 T33 T34 D56
• Catalytic site (residue number reindexed from 1): G23 G25 K26 T27 T28 D50
• Enzyme Commision number: 3.6.-.-

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0032977 membrane insertase activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0045048 protein insertion into ER membrane
• GO:0071816 tail-anchored membrane protein insertion into ER membrane

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum
• GO:0005829 cytosol
• GO:0043529 GET complex

External links

• PDB: RCSB:2woo, PDBe:2woo, PDBj:2woo
• PDBsum: 2woo
• PubMed: 19675567
• UniProt: Q9P7F8|GET3_SCHPO ATPase get3 (Gene Name=get3)