Structure of PDB 2wn2 Chain C Binding Site BS01

Receptor Information
>2wn2 Chain C (length=253) Species: 366501 (Dictyostelium discoideum AX2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MSTQGLVQLLANAQCHLRTSTNYNGVHTQFNSALNYKNNGTNTIDGSEAW
CSSIVDTNQYIVAGCEVPRTFMCVALQGRGDADQWVTSYKIRYSLDNVSW
FEYRNGAAVTGVTDRNTVVNHFFDTPIRARSIAIHPLTWNGHISLRCEFY
TQPVQSSVTQVGADIYTGDNCALNTGSGKREVVVPVKFQFEFATLPKVAL
NFDQIDCTDATNQTRIGVQPRNITTKGFDCVFYTWNENKVYSLRADYIAT
ALE
Ligand information
Ligand IDGAL
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-FPRJBGLDSA-N
SMILES
SoftwareSMILES
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O
OpenEye OEToolkits 1.7.2C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
OpenEye OEToolkits 1.7.2C([C@@H]1[C@@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
FormulaC6 H12 O6
Namebeta-D-galactopyranose;
beta-D-galactose;
D-galactose;
galactose
ChEMBLCHEMBL300520
DrugBank
ZINCZINC000002597049
PDB chain2wn2 Chain F Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2wn2 Discoidin I from Dictyostelium Discoideum and Interactions with Oligosaccharides: Specificity, Affinity, Crystal Structures and Comparison with Discoidin II.
Resolution1.82 Å
Binding residue
(original residue number in PDB)		Y166 D206 Y241 S242
Binding residue
(residue number reindexed from 1)		Y166 D206 Y241 S242
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030246 carbohydrate binding
GO:0030247 polysaccharide binding
GO:0046871 N-acetylgalactosamine binding
GO:0070492 oligosaccharide binding
GO:1990458 lipooligosaccharide binding
Biological Process
GO:0000281 mitotic cytokinesis
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0009617 response to bacterium
GO:0010468 regulation of gene expression
GO:0019954 asexual reproduction
GO:0030865 cortical cytoskeleton organization
GO:0031589 cell-substrate adhesion
GO:0061635 regulation of protein complex stability
GO:0072697 protein localization to cell cortex
GO:0098609 cell-cell adhesion
GO:0106136 lectin-induced modified bacterial internalization
GO:1902168 response to catechin
GO:1904643 response to curcumin
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005938 cell cortex
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0045335 phagocytic vesicle
GO:0097708 intracellular vesicle
GO:0098636 protein complex involved in cell adhesion
GO:0106139 symbiont cell surface

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2wn2, PDBe:2wn2, PDBj:2wn2
PDBsum2wn2
PubMed20580724
UniProtP02886|DIS1A_DICDI Discoidin-1 subunit A (Gene Name=dscA-1)

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