Structure of PDB 2qts Chain C Binding Site BS01

Receptor Information

>2qts Chain C (length=418) Species: 9031 (Gallus gallus)

LSLKRVVWALCFMGSLALLALVCTNRIQYYFLYPHVTKLDEVAATRLTFP
AVTFCNLNEFRFSRVTKNDLYHAGELLALLNNRYEIPDTQTADEKQLEIL
QDKANFRNFKPKPFNMLEFYDRAGHDIREMLLSCFFRGEQCSPEDFKVVF
TRYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDE
TSFEAGIKVQIHSQDEPPLIDQLGFGVAPGFQTFVSCQEQRLIYLPPPWG
DCKATTGDSEFYDTYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPE
QYKECADPALDFLVEKDNEYCVCEMPCNVTRYGKELSMVKIPSKASAKYL
AKKYNKSEQYIGENILVLDIFFEALNYETIEQKKAYEVAGLLGDIGGQMG
LFIGASILTVLELFDYAY

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 2qts Chain G Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2qts Structure of acid-sensing ion channel 1 at 1.9A resolution and low pH
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): G436 L440
• Binding residue (residue number reindexed from 1): G397 L401
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0005272 sodium channel activity
• GO:0015280 ligand-gated sodium channel activity

Biological Process

• GO:0006814 sodium ion transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:2qts, PDBe:2qts, PDBj:2qts
• PDBsum: 2qts
• PubMed: 17882215
• UniProt: Q1XA76|ASIC1_CHICK Acid-sensing ion channel 1 (Gene Name=ASIC1)