Structure of PDB 2pqj Chain C Binding Site BS01

Receptor Information
>2pqj Chain C (length=232) Species: 4577 (Zea mays) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFTEIFPVEDANYPYSAFIASVRKDVIKHCTDHKGIFQPVLPPEKKVPEL
WLYTELKTRTSSITLAIRMDNLYLVGFRTPGGVWWEFGKDGDTHLLGDNP
RWLGFGGRYQDLIGNKGLETVTMGRAEMTRAVNDLAKKKKMPQADTKSKL
VKLVVMVCEGLRFNTVSRTVDAGFNSQVTLTVTQGKQVQKWDRISKAAFE
WADHPTAVIPDMQKLGIKDKNEAARIVALVKN
Ligand information
Ligand IDADE
InChIInChI=1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)
InChIKeyGFFGJBXGBJISGV-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Nc1ncnc2[nH]cnc12
OpenEye OEToolkits 1.5.0c1[nH]c2c(n1)c(ncn2)N
ACDLabs 10.04n1c(c2ncnc2nc1)N
FormulaC5 H5 N5
NameADENINE
ChEMBLCHEMBL226345
DrugBankDB00173
ZINCZINC000000000882
PDB chain2pqj Chain C Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2pqj Structure-function study of maize ribosome-inactivating protein: implications for the internal inactivation region and the sole glutamate in the active site.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Y94 L95 G128 V202 C206
Binding residue
(residue number reindexed from 1)		Y73 L74 G107 V154 C158
Annotation score4
Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:2pqj, PDBe:2pqj, PDBj:2pqj
PDBsum2pqj
PubMed17855394
UniProtP25891|RIP3_MAIZE Ribosome-inactivating protein 3 (Gene Name=CRIP3)

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