Structure of PDB 2pe5 Chain C Binding Site BS01

Receptor Information
>2pe5 Chain C (length=328) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPVTLYDVAEYAGVSYQTVSRVVNQASHVSAKTREKVEAAMAELNYIPNR
VAQQLAGKQLLLIGVATSSLALHAPSQIVAAIKSRADQLGASVVVSMVER
SGVEACKAAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPALFLDVS
DQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSARLRLAGW
HKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVANDQMAL
GAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRLLGQTSV
DRLLQLSQGQAVKGNQLLPVSLVKRKTT
Ligand information
Receptor-Ligand Complex Structure
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PDB2pe5 Structural analysis of lac repressor bound to allosteric effectors
Resolution3.5 Å
Binding residue
(original residue number in PDB)		T5 L6 Q18 S21 Y47 N50 A53 Q54
Binding residue
(residue number reindexed from 1)		T4 L5 Q17 S20 Y46 N49 A52 Q53
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pe5, PDBe:2pe5, PDBj:2pe5
PDBsum2pe5
PubMed17543986
UniProtP03023|LACI_ECOLI Lactose operon repressor (Gene Name=lacI)

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