Structure of PDB 2p6b Chain C Binding Site BS01

Receptor Information
>2p6b Chain C (length=357) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALR
IITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRY
LFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFK
QECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEINTLDDIR
KLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYP
AVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLD
VYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTE
MLVNVLN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2p6b Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction
Resolution2.3 Å
Binding residue
(original residue number in PDB)		F299 K318 N327 V328 M329 N330 I331
Binding residue
(residue number reindexed from 1)		F286 K305 N314 V315 M316 N317 I318
Enzymatic activity
Catalytic site (original residue number in PDB) G106 P108 W134 K137 I138 C166 K167 H199
Catalytic site (residue number reindexed from 1) G93 P95 W121 K124 I125 C153 K154 H186
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0033192 calmodulin-dependent protein phosphatase activity
Biological Process
GO:0097720 calcineurin-mediated signaling

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Molecular Function
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Biological Process
External links
PDB RCSB:2p6b, PDBe:2p6b, PDBj:2p6b
PDBsum2p6b
PubMed17498738
UniProtQ08209|PP2BA_HUMAN Protein phosphatase 3 catalytic subunit alpha (Gene Name=PPP3CA)

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