Structure of PDB 2okv Chain C Binding Site BS01

Receptor Information

>2okv Chain C (length=149) Species: 9606 (Homo sapiens)

MKAVVQRVTRASVTVGGEQISAIGRGICVLLGISLEDTQKELEHMVRKIL
NLRVFEDESGKHWSKSVMDKQYEILCVSQFTLQCVLKGNKPDFHLAMPTE
QAEGFYNSFLEQLRKTYRPELIKDGKFGAYMQVHIQNDGPVTIELESPA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2okv Chain C Residue 1202

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2okv Structure and Function of the c-myc DNA-unwinding Element-binding Protein DUE-B.
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): V4 Q6 C28 L30
• Binding residue (residue number reindexed from 1): V4 Q6 C28 L30
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): Q79 F80 T81
• Catalytic site (residue number reindexed from 1): Q79 F80 T81
• Enzyme Commision number: 3.1.1.96: D-aminoacyl-tRNA deacylase.

Gene Ontology

Molecular Function

• GO:0000049 tRNA binding
• GO:0002161 aminoacyl-tRNA editing activity
• GO:0003677 DNA binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding
• GO:0051499 D-aminoacyl-tRNA deacylase activity
• GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity

Biological Process

• GO:0006260 DNA replication
• GO:0006399 tRNA metabolic process
• GO:0032508 DNA duplex unwinding
• GO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005739 mitochondrion

External links

• PDB: RCSB:2okv, PDBe:2okv, PDBj:2okv
• PDBsum: 2okv
• PubMed: 17264083
• UniProt: Q8TEA8|DTD1_HUMAN D-aminoacyl-tRNA deacylase 1 (Gene Name=DTD1)