Structure of PDB 2o8j Chain C Binding Site BS01

Receptor Information

>2o8j Chain C (length=262) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNIDRNITHL
QHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKIEPPLIFECNQAC
SCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGEL
ISDAEADVREDDSYLFDLEVYCIDARYYGNISRFINHLCDPNIIPVRVFM
LHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFTCQCGSEKCK
HSAEAIALEQSR

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2o8j Chain C Residue 1509 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2o8j Structural biology of human H3K9 methyltransferases
Resolution	1.8 Å
Binding residue (original residue number in PDB)	C974 C987 C1017 C1021
Binding residue (residue number reindexed from 1)	C53 C66 C96 C100
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	Y1067 Y1154
Catalytic site (residue number reindexed from 1)	Y146 Y228
Enzyme Commision number	2.1.1.- 2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Gene Ontology

	Molecular Function
GO:0002039	p53 binding
GO:0008270	zinc ion binding
GO:0016279	protein-lysine N-methyltransferase activity
GO:0042054	histone methyltransferase activity

	Cellular Component
GO:0005634	nucleus

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Molecular Function

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Cellular Component

External links

PDB	RCSB:2o8j, PDBe:2o8j, PDBj:2o8j
PDBsum	2o8j
PubMed	20084102
UniProt	Q96KQ7\|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)

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