Structure of PDB 2o74 Chain C Binding Site BS01

Receptor Information
>2o74 Chain C (length=167) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDINVVNALAYEDFVKLFGNVVEKCPLISAAIWSYRPFKDLADIEARISE
FIHSLPDSGKEGILRCHPDLAGRDLQSGTLTPESQEEQSQAGMTTLDSAE
IVHMYRLNSEYKERFGFPFVICARLNNKADIVRQLSERLKNRRTAELECA
IEEVKKICSLRLHSIVL
Ligand information
Ligand IDGUN
InChIInChI=1S/C5H5N5O/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
InChIKeyUYTPUPDQBNUYGX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2[nH]cnc2C(=O)N1
ACDLabs 10.04O=C1c2ncnc2N=C(N1)N
OpenEye OEToolkits 1.5.0c1[nH]c2c(n1)C(=O)NC(=N2)N
FormulaC5 H5 N5 O
NameGUANINE
ChEMBLCHEMBL219568
DrugBankDB02377
ZINCZINC000000895129
PDB chain2o74 Chain C Residue 3001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2o74 The structure of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase provides insights into the mechanism of uric acid degradation.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		P68 L70 S84 E87 Q88 F119 I121 A123
Binding residue
(residue number reindexed from 1)		P68 L70 S84 E87 Q88 F119 I121 A123
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.1.97: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase.
Gene Ontology
Molecular Function
GO:0016831 carboxy-lyase activity
GO:0051997 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity
Biological Process
GO:0000255 allantoin metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0019628 urate catabolic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2o74, PDBe:2o74, PDBj:2o74
PDBsum2o74
PubMed17428786
UniProtA1L259|URAD_DANRE 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (Gene Name=urad)

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